AXIN2 rs2240308 polymorphism contributes to increased cancer risk: evidence based on a meta-analysis
نویسندگان
چکیده
منابع مشابه
−148 C/T polymorphism of Axin2 contributes to a decreased risk of cancer: evidence from a meta-analysis
Several studies have reported an association between -148 C/T polymorphism of Axis inhibition protein 2 (Axin2) and cancer risk; however, the results are inconsistent. In this study, a meta-analysis was performed to assess the association between -148 C/T polymorphism of Axin2 and susceptibility to cancer. Published case-control and cohort-based studies from PubMed, Embase, Wanfang, and CNKI we...
متن کاملQuantitative assessment of the association between AXIN2 rs2240308 polymorphism and cancer risk
Axin2 is involved in the regulation of Wnt/β-catenin pathway and implicated in cancer development and progression. The association between AXIN2 rs2240308 polymorphism and cancer risk has been examined in several case-control studies, but the conclusions were conflicting. Here we performed a meta-analysis to evaluate the role of rs2240308 in cancer risk. A total of 8 studies were included in th...
متن کاملSignificant association between the Axin2 rs2240308 single nucleotide polymorphism and the incidence of prostate cancer
The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single nucleotide polymorphism (SNP) rs2240308 [guanine (G)/adenine (A)] and the inc...
متن کاملTERT-CLPTM1L Polymorphism rs401681 Contributes to Cancers Risk: Evidence from a Meta-Analysis Based on 29 Publications
BACKGROUND Some common genetic variants of TERT-CLPTM1L gene, which encode key protein subunits of telomerase, have been suggested to play a crucial role in tumorigenesis. The TERT-CLPTM1L polymorphism rs401681 was of special interest for cancers risk but with inconclusive results. METHODOLOGY/PRINCIPAL FINDINGS We performed a comprehensive meta-analysis of 29 publications with a total of 912...
متن کاملARLTS1 polymorphism is associated with an increased risk of familial cancer: evidence from a meta-analysis
Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1(ARLTS1) might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with ARLTS1 polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by ...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2015
ISSN: 1475-2867
DOI: 10.1186/s12935-015-0219-8